Histomorphological skin changes in the wound healing process after surgical intervention

Introduction: The process of wound healing is best represented by an uninfected surgical wound. It characterized the formation granulation tissue, with migration and proliferation fibroblasts, neoangiogenesis production extracellular matrix. Granulation tissue gradually replaced scar made up connective and, in most cases - ended three or four weeks. whole takes about six weeks a newly formed has approximately 90% strength intact skin. Aim: aim this paper examination histomorphological changes skin during first intention. Material methods: Six groups are based on age wounds. In each group we searched for epidermis, collagen fibers, capillaries, inflammatory infiltrate hypodermis. Tissue biopsies were stained hematoxylin-eosin, Mallory trichrome stain, silver impregnation immunohistochemically CD31, IV h-caldesmon. Results: Analyzing wounds different stages have observed that could be described chronologically. chose representative biopsy visible location cut, clear histological repairing specific every period. Conclusion: After incision, repair place to form new from surrounding shows irregular architectonics loss appendages dermis, thicker epidermis.